p21WAF1/CIP1 Expression is Differentially Regulated by Metformin and Rapamycin

The mammalian target of rapamycin (mTOR) pathway plays an important role in the development of diabetic nephropathy and other age-related diseases. One of the features of DN is the elevated expression of p21WAF1/CIP1. However, the importance of the mTOR signalling pathway in p21 regulation is poorly...

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Bibliographic Details
Main Authors: Zoltan Molnar, Ann B. Millward, Wai Tse, Andrew G. Demaine
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:International Journal of Chronic Diseases
Online Access:http://dx.doi.org/10.1155/2014/327640