The antihypertensive effect and mechanisms of bioactive peptides from Ruditapes philippinarum fermented with Bacillus natto in spontaneously hypertensive rats
In our previous study, the clams (Ruditapes philippinarum) were inoculated with Bacillus natto and fermented to produce peptides (RBPs) with high ACE inhibitory effect in vitro. In this study, we continued to explore the anti-hypertensive effect and potential mechanisms of RBPs in vivo. The results...
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doaj-13d6fcfd21b3418aa15446eae57194d92021-04-30T07:20:44ZengElsevierJournal of Functional Foods1756-46462021-04-0179104411The antihypertensive effect and mechanisms of bioactive peptides from Ruditapes philippinarum fermented with Bacillus natto in spontaneously hypertensive ratsYahui Song0Jia Yu1Jiale Song2Shanglong Wang3Tingfeng Cao4Zimin Liu5Xiang Gao6Yuxi Wei7College of Life Sciences, Qingdao University, Qingdao, Shandong 266071, ChinaCollege of Life Sciences, Qingdao University, Qingdao, Shandong 266071, ChinaCollege of Life Sciences, Qingdao University, Qingdao, Shandong 266071, ChinaChenland Nutritionals, Inc, Irvine, CA 92614, United StatesChenland Nutritionals, Inc, Irvine, CA 92614, United StatesChenland Nutritionals, Inc, Irvine, CA 92614, United StatesCollege of Life Sciences, Qingdao University, Qingdao, Shandong 266071, China; Corresponding authors at: College of Life Sciences, Qingdao University, 308 Ningxia Road, Qingdao 266071, China.College of Life Sciences, Qingdao University, Qingdao, Shandong 266071, China; Corresponding authors at: College of Life Sciences, Qingdao University, 308 Ningxia Road, Qingdao 266071, China.In our previous study, the clams (Ruditapes philippinarum) were inoculated with Bacillus natto and fermented to produce peptides (RBPs) with high ACE inhibitory effect in vitro. In this study, we continued to explore the anti-hypertensive effect and potential mechanisms of RBPs in vivo. The results showed that RBPs significantly reduced both systolic and diastolic blood pressure and alleviated the damage of kidney, thoracic aorta and heart of spontaneously hypertensive rats after 8 weeks of treatment. Meanwhile, RBPs could also inhibit the expression of RAS signaling pathway, maintained the secretion balance of NO/ET-1 in vascular endothelial cells and inhibited the cardiac TGF-β/Smad pathway. Most notably, RBPs could also improve the gut microbiota by decreasing the ratio of Firmicutes and Bacteroidetes and increasing the relative abundance of certain genera, like Ruminococcaceae_UCG-014. The data suggested that RBPs could be used as functional food ingredient for the improvement of hypertension.http://www.sciencedirect.com/science/article/pii/S1756464621000608Ruditapes philippinarumBacillus nattoPeptidesAntihypertensionRats |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yahui Song Jia Yu Jiale Song Shanglong Wang Tingfeng Cao Zimin Liu Xiang Gao Yuxi Wei |
spellingShingle |
Yahui Song Jia Yu Jiale Song Shanglong Wang Tingfeng Cao Zimin Liu Xiang Gao Yuxi Wei The antihypertensive effect and mechanisms of bioactive peptides from Ruditapes philippinarum fermented with Bacillus natto in spontaneously hypertensive rats Journal of Functional Foods Ruditapes philippinarum Bacillus natto Peptides Antihypertension Rats |
author_facet |
Yahui Song Jia Yu Jiale Song Shanglong Wang Tingfeng Cao Zimin Liu Xiang Gao Yuxi Wei |
author_sort |
Yahui Song |
title |
The antihypertensive effect and mechanisms of bioactive peptides from Ruditapes philippinarum fermented with Bacillus natto in spontaneously hypertensive rats |
title_short |
The antihypertensive effect and mechanisms of bioactive peptides from Ruditapes philippinarum fermented with Bacillus natto in spontaneously hypertensive rats |
title_full |
The antihypertensive effect and mechanisms of bioactive peptides from Ruditapes philippinarum fermented with Bacillus natto in spontaneously hypertensive rats |
title_fullStr |
The antihypertensive effect and mechanisms of bioactive peptides from Ruditapes philippinarum fermented with Bacillus natto in spontaneously hypertensive rats |
title_full_unstemmed |
The antihypertensive effect and mechanisms of bioactive peptides from Ruditapes philippinarum fermented with Bacillus natto in spontaneously hypertensive rats |
title_sort |
antihypertensive effect and mechanisms of bioactive peptides from ruditapes philippinarum fermented with bacillus natto in spontaneously hypertensive rats |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2021-04-01 |
description |
In our previous study, the clams (Ruditapes philippinarum) were inoculated with Bacillus natto and fermented to produce peptides (RBPs) with high ACE inhibitory effect in vitro. In this study, we continued to explore the anti-hypertensive effect and potential mechanisms of RBPs in vivo. The results showed that RBPs significantly reduced both systolic and diastolic blood pressure and alleviated the damage of kidney, thoracic aorta and heart of spontaneously hypertensive rats after 8 weeks of treatment. Meanwhile, RBPs could also inhibit the expression of RAS signaling pathway, maintained the secretion balance of NO/ET-1 in vascular endothelial cells and inhibited the cardiac TGF-β/Smad pathway. Most notably, RBPs could also improve the gut microbiota by decreasing the ratio of Firmicutes and Bacteroidetes and increasing the relative abundance of certain genera, like Ruminococcaceae_UCG-014. The data suggested that RBPs could be used as functional food ingredient for the improvement of hypertension. |
topic |
Ruditapes philippinarum Bacillus natto Peptides Antihypertension Rats |
url |
http://www.sciencedirect.com/science/article/pii/S1756464621000608 |
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