NGL-1/LRRC4C-Mutant Mice Display Hyperactivity and Anxiolytic-Like Behavior Associated With Widespread Suppression of Neuronal Activity

NGL-1/LRRC4C-Mutant Mice Display Hyperactivity and Anxiolytic-Like Behavior Associated With Widespread Suppression of Neuronal Activity

Netrin-G ligand-1 (NGL-1), encoded by Lrrc4c, is a post-synaptic adhesion molecule implicated in various brain disorders, including bipolar disorder, autism spectrum disorder, and developmental delay. Although previous studies have explored the roles of NGL-1 in the regulation of synapse development...

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Bibliographic Details
Main Authors: Yeonsoo Choi, Haram Park, Suwon Kang, Hwajin Jung, Hanseul Kweon, Seoyeong Kim, Ilsong Choi, Soo Yeon Lee, Ye-Eun Choi, Seung-Hee Lee, Eunjoon Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
NGL-1
LRRC4C
synaptic adhesion molecule
hyperactivity
anxiety
learning and memory
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00250/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2019.00250/full

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