Complement component C3 and butyrylcholinesterase activity are associated with neurodegeneration and clinical disability in multiple sclerosis.

Complement component C3 and butyrylcholinesterase activity are associated with neurodegeneration and clinical disability in multiple sclerosis.

Dysregulation of the complement system is evident in many CNS diseases but mechanisms regulating complement activation in the CNS remain unclear. In a recent large rat genome-wide expression profiling and linkage analysis we found co-regulation of complement C3 immediately downstream of butyrylcholi...

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Main Authors: Shahin Aeinehband, Rickard P F Lindblom, Faiez Al Nimer, Swetha Vijayaraghavan, Kerstin Sandholm, Mohsen Khademi, Tomas Olsson, Bo Nilsson, Kristina Nilsson Ekdahl, Taher Darreh-Shori, Fredrik Piehl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4383591?pdf=render

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http://europepmc.org/articles/PMC4383591?pdf=render

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