Natural and Semisynthetic Analogues of Manadoperoxide B Reveal New Structural Requirements for Trypanocidal Activity

Natural and Semisynthetic Analogues of Manadoperoxide B Reveal New Structural Requirements for Trypanocidal Activity

Chemical analysis of the Indonesian sponge Plakortis cfr. lita afforded two new analogues of the potent trypanocidal agent manadoperoxide B (1), namely 12-isomanadoperoxide B (2) and manadoperoxidic acid B (3). These compounds were isolated along with a new short chain dicarboxylate monoester (4), b...

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Bibliographic Details
Main Authors: Orazio Taglialatela-Scafati, Deniz Tasdemir, Marcel Kaiser, Henny A. Dien, Barbara Calcinai, Carlo Cerrano, Fernando Scala, Giuseppina Chianese
Format: Article
Language:English
Published: MDPI AG 2013-08-01
Series:Marine Drugs
Subjects:
manadoperoxide B
marine antitrypanosomals
structure–activity relationships
Online Access:http://www.mdpi.com/1660-3397/11/9/3297

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http://www.mdpi.com/1660-3397/11/9/3297

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