Ensemble Kinetic Modeling of Metabolic Networks from Dynamic Metabolic Profiles

Ensemble Kinetic Modeling of Metabolic Networks from Dynamic Metabolic Profiles

Kinetic modeling of metabolic pathways has important applications in metabolic engineering, but significant challenges still remain. The difficulties faced vary from finding best-fit parameters in a highly multidimensional search space to incomplete parameter identifiability. To meet some of these c...

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Bibliographic Details
Main Authors: Gengjie Jia, Gregory Stephanopoulos, Rudiyanto Gunawan
Format: Article
Language:English
Published: MDPI AG 2012-11-01
Series:Metabolites
Subjects:
ensemble modeling
incremental identification
dynamic flux estimation
independent parameter set
generalized mass action model
Online Access:http://www.mdpi.com/2218-1989/2/4/891

Internet

http://www.mdpi.com/2218-1989/2/4/891

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