Identification of key residues that confer Rhodobacter sphaeroides LPS activity at horse TLR4/MD-2.

Identification of key residues that confer Rhodobacter sphaeroides LPS activity at horse TLR4/MD-2.

The molecular determinants underpinning how hexaacylated lipid A and tetraacylated precursor lipid IVa activate Toll-like receptor 4 (TLR4) are well understood, but how activation is induced by other lipid A species is less clear. Species specificity studies have clarified how TLR4/MD-2 recognises d...

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Bibliographic Details
Main Authors: Katherine L Irvine, Monique Gangloff, Catherine M Walsh, David R Spring, Nicholas J Gay, Clare E Bryant
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4039514?pdf=render

Internet

http://europepmc.org/articles/PMC4039514?pdf=render

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