3D-QSAR and molecular docking analysis of (4-piperidinyl)-piperazines as acetyl-CoA carboxylases inhibitors

3D-QSAR and molecular docking analysis of (4-piperidinyl)-piperazines as acetyl-CoA carboxylases inhibitors

Acetyl-CoA carboxylase (ACC) is a crucial metabolic enzyme, which plays a vital role in fatty acid metabolism and obesity induced type 2 diabetes. Herein, we have performed 3D-QSAR and molecular docking analysis on a novel series of (4-piperidinyl)-piperazines to design potent ACC inhibitors. This s...

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Bibliographic Details
Main Authors: Udghosh Singh, Rahul Prakashchand Gangwal, Gaurao V. Dhoke, Rameshwar Prajapati, Mangesh Damre, Abhay T. Sangamwar
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Arabian Journal of Chemistry
Subjects:
Acetyl-CoA carboxylases
(4-Piperidinyl)-piperazines
CoMFA
CoMSIA
Molecular docking
LeapFrog
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535212002559

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http://www.sciencedirect.com/science/article/pii/S1878535212002559

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