Functional and genetic determinants of mutation rate variability in regulatory elements of cancer genomes
Abstract Background Cancer genomes are shaped by mutational processes with complex spatial variation at multiple scales. Entire classes of regulatory elements are affected by local variations in mutation frequency. However, the underlying mechanisms with functional and genetic determinants remain po...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-05-01
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| Series: | Genome Biology |
| Online Access: | https://doi.org/10.1186/s13059-021-02318-x |