Hierarchical nanostructure and synergy of multimolecular signalling complexes

Imaging the nanostructure of signalling complexes in cells is challenging. Here, the authors present a multicolour, single-molecule, super-resolution approach with statistical tools to reveal a hierarchical topology and synergy of signalling complexes downstream of the T-cell receptor in fixed and l...

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Bibliographic Details
Main Authors: Eilon Sherman, Valarie A. Barr, Robert K. Merrill, Carole K. Regan, Connie L. Sommers, Lawrence E. Samelson
Format: Article
Language:English
Published: Nature Publishing Group 2016-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12161