Protein disulphide isomerase inhibition as a potential cancer therapeutic strategy

Abstract The protein disulphide isomerase (PDI) gene family is a large, diverse group of enzymes recognised for their roles in disulphide bond formation within the endoplasmic reticulum (ER). PDI therefore plays an important role in ER proteostasis, however, it also shows involvement in ER stress, a...

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Bibliographic Details
Main Authors: Lauren E. Powell, Paul A. Foster
Format: Article
Language:English
Published: Wiley 2021-04-01
Series:Cancer Medicine
Subjects:
Online Access:https://doi.org/10.1002/cam4.3836