Essential Function of Dicer in Resolving DNA Damage in the Rapidly Dividing Cells of the Developing and Malignant Cerebellum

Essential Function of Dicer in Resolving DNA Damage in the Rapidly Dividing Cells of the Developing and Malignant Cerebellum

Maintenance of genomic integrity is critical during neurodevelopment, particularly in rapidly dividing cerebellar granule neuronal precursors that experience constitutive replication-associated DNA damage. As Dicer was recently recognized to have an unexpected function in the DNA damage response, we...

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Bibliographic Details
Main Authors: Vijay Swahari, Ayumi Nakamura, Jeanette Baran-Gale, Idoia Garcia, Andrew J. Crowther, Robert Sons, Timothy R. Gershon, Scott Hammond, Praveen Sethupathy, Mohanish Deshmukh
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Cell Reports
Subjects:
dicer
replicative stress
medulloblastoma
apoptosis
p53
embryonic stem cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715014618

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http://www.sciencedirect.com/science/article/pii/S2211124715014618

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