Paraoxonase (PON1 and PON3) polymorphisms: impact on liver expression and atorvastatin-lactone hydrolysis

Paraoxonase (PON1 and PON3) polymorphisms: impact on liver expression and atorvastatin-lactone hydrolysis

Atorvastatin δ-lactone, a major, pharmacologically inactive metabolite, has been associated with toxicity. In a previous study we showed that polymorphisms of UGT1A3 influence atorvastatin δ-lactone formation. Here we investigated the reverse reaction, atorvastatin δ-lactone hydrolysis, in a human l...

Full description

Bibliographic Details
Main Authors: Stephan eRiedmaier, Kathrin eKlein, Stefan eWinter, Ute eHofmann, Matthias eSchwab, Ulrich M Zanger
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-07-01
Series:Frontiers in Pharmacology
Subjects:
Pharmacogenetics
Rhabdomyolysis
pharmacogenomics
SNP
Myopathy
atorvastatin-lactone
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00041/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00041/full

Similar Items