Multidrug transporters: recent insights from cryo-electron microscopy-derived atomic structures and animal models [version 1; peer review: 2 approved]
P-glycoprotein, ABCG2, and MRP1 are members of the ATP-binding cassette (ABC) transporter superfamily that utilize energy from ATP-binding and hydrolysis to efflux a broad range of chemically dissimilar substrates including anticancer drugs. As a consequence, they play an important role in the pharm...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
F1000 Research Ltd
2020-01-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/9-17/v1 |