PAM50 Intrinsic Subtype Profiles in Primary and Metastatic Breast Cancer Show a Significant Shift toward More Aggressive Subtypes with Prognostic Implications

PAM50 Intrinsic Subtype Profiles in Primary and Metastatic Breast Cancer Show a Significant Shift toward More Aggressive Subtypes with Prognostic Implications

Background: PAM50 breast cancer intrinsic subtyping adds prognostic information in early breast cancer; however, the role in metastatic disease is unclear. We aimed to identify PAM50 subtypes in primary tumors (PTs) and metastases to outline subtype changes and their prognostic role. Methods: RNA wa...

Full description

Bibliographic Details
Main Authors: Charlotte Levin Tykjær Jørgensen, Anna-Maria Larsson, Carina Forsare, Kristina Aaltonen, Sara Jansson, Rachel Bradshaw, Pär-Ola Bendahl, Lisa Rydén
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
metastatic breast cancer
PAM50 breast cancer intrinsic subtype
tumor progression
subtype shift
tumor heterogeneity
Online Access:https://www.mdpi.com/2072-6694/13/7/1592

Internet

https://www.mdpi.com/2072-6694/13/7/1592

Similar Items