An N-ethyl-N-Nitrosourea Mutagenesis Screen in Mice Reveals a Mutation in <i>Nuclear Respiratory Factor 1</i> (<i>Nrf1)</i> Altering the DNA Methylation State and Correct Embryonic Development

An N-ethyl-N-Nitrosourea Mutagenesis Screen in Mice Reveals a Mutation in <i>Nuclear Respiratory Factor 1</i> (<i>Nrf1)</i> Altering the DNA Methylation State and Correct Embryonic Development

We have established a genome-wide N-ethyl-N-nitrosourea (ENU) mutagenesis screen to identify novel genes playing a role in epigenetic regulation in mammals. We hypothesize that the ENU mutagenesis screen will lead to the discovery of unknown genes responsible of the maintenance of the epigenetic sta...

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Bibliographic Details
Main Authors: Maria Alba Sorolla, Marta Marqués, Eva Parisi, Anabel Sorolla
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Animals
Subjects:
NRF1
Nrf1
ENU mutagenesis
epigenetics
transcription factor
embryonic development
Online Access:https://www.mdpi.com/2076-2615/11/7/2103

Internet

https://www.mdpi.com/2076-2615/11/7/2103

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