Immune responses in the treatment of drug-sensitive pulmonary tuberculosis with phenylbutyrate and vitamin D3 as host directed therapy

Immune responses in the treatment of drug-sensitive pulmonary tuberculosis with phenylbutyrate and vitamin D3 as host directed therapy

Abstract Background We have previously shown that 8 weeks’ treatment with phenylbutyrate (PBA) (500mgx2/day) with or without vitamin D3 (vitD3) (5000 IU/day) as host-directed therapy (HDT) accelerated clinical recovery, sputum culture conversion and increased expression of cathelicidin LL-37 by immu...

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Bibliographic Details
Main Authors: Rokeya Sultana Rekha, Akhirunnesa Mily, Tajnin Sultana, Ahsanul Haq, Sultan Ahmed, S. M. Mostafa Kamal, Annemarie van Schadewijk, Pieter S. Hiemstra, Gudmundur H. Gudmundsson, Birgitta Agerberth, Rubhana Raqib
Format: Article
Language:English
Published: BMC 2018-07-01
Series:BMC Infectious Diseases
Subjects:
Mycobacterium tuberculosis
Cytokines
Chemokines
Endoplasmic reticulum stress
Human beta-defensin-1 (HBD1)
Online Access:http://link.springer.com/article/10.1186/s12879-018-3203-9

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http://link.springer.com/article/10.1186/s12879-018-3203-9

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