Donor Heme Oxygenase-1 Promoter Gene Polymorphism Predicts Survival after Unrelated Bone Marrow Transplantation for High-Risk Patients

Donor Heme Oxygenase-1 Promoter Gene Polymorphism Predicts Survival after Unrelated Bone Marrow Transplantation for High-Risk Patients

Heme oxygenase-1 (HO-1), an intracellular enzyme that catalyzes the degradation of heme into biliverdin, free iron, and carbon monoxide, exerts anti-inflammatory and cytoprotective effects against endothelial cell injury. The <i>HO-1</i> promoter gene has one important single-nucleotide...

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Bibliographic Details
Main Authors: Tomohiro Horio, Eriko Morishita, Shohei Mizuno, Kaori Uchino, Ichiro Hanamura, J. Luis Espinoza, Yasuo Morishima, Yoshihisa Kodera, Makoto Onizuka, Koichi Kashiwase, Takahiro Fukuda, Noriko Doki, Koichi Miyamura, Takehiko Mori, Shinji Nakao, Akiyoshi Takami
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cancers
Subjects:
<i>ho-1</i>
unrelated donor
bone marrow transplantation
single nucleotide polymorphism
Online Access:https://www.mdpi.com/2072-6694/12/2/424

Internet

https://www.mdpi.com/2072-6694/12/2/424

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