Down Regulation of c-FLIPL Enhance PD-1 Blockade Efficacy in B16 Melanoma

Down Regulation of c-FLIPL Enhance PD-1 Blockade Efficacy in B16 Melanoma

Immune checkpoint blockade of programmed cell death protein 1 (PD-1) had an impressive long-lasting effect in a portion of advanced-stage melanoma patients, however, this therapy failed to induce responses in several patients; how to increase the objective response rate is very important. Cellular F...

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Bibliographic Details
Main Authors: Yao Wang, Jing-jing Li, Hong-jun Ba, Ke-feng Wang, Xi-zhi Wen, Dan-dan Li, Xiao-feng Zhu, Xiao-shi Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Oncology
Subjects:
c-FLIPL
PD-1
PD-L1
B16 melanoma
immune therapy
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00857/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.00857/full

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