Conotoxins Targeting Neuronal Voltage-Gated Sodium Channel Subtypes: Potential Analgesics?

Voltage-gated sodium channels (VGSC) are the primary mediators of electrical signal amplification and propagation in excitable cells. VGSC subtypes are diverse, with different biophysical and pharmacological properties, and varied tissue distribution. Altered VGSC expression and/or increased VGSC ac...

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Bibliographic Details
Main Authors: Jeffrey R. McArthur, Oliver Knapp, David J. Adams
Format: Article
Language:English
Published: MDPI AG 2012-11-01
Series:Toxins
Subjects:
Online Access:http://www.mdpi.com/2072-6651/4/11/1236