Aptamer-Mediated Codelivery of Doxorubicin and NF-κB Decoy Enhances Chemosensitivity of Pancreatic Tumor Cells

Aptamer-Mediated Codelivery of Doxorubicin and NF-κB Decoy Enhances Chemosensitivity of Pancreatic Tumor Cells

Aptamers able to bind efficiently cell-surface receptors differentially expressed in tumor and in healthy cells are emerging as powerful tools to perform targeted anticancer therapy. Here, we present a novel oligonucleotide chimera, composed by an RNA aptamer and a DNA decoy. Our assembly is able to...

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Bibliographic Details
Main Authors: David Porciani, Lorena Tedeschi, Laura Marchetti, Lorenzo Citti, Vincenzo Piazza, Fabio Beltram, Giovanni Signore
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
aptamer-decoy chimera
nucleic acid aptamer
aptamer-mediated codelivery
NF-κB decoy
targeted delivery
Online Access:http://www.sciencedirect.com/science/article/pii/S216225311630021X

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http://www.sciencedirect.com/science/article/pii/S216225311630021X

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