An immunofluorescence assay for extracellular matrix components highlights the role of epithelial cells in producing a stable, fibrillar extracellular matrix

An immunofluorescence assay for extracellular matrix components highlights the role of epithelial cells in producing a stable, fibrillar extracellular matrix

Activated fibroblasts are considered major drivers of fibrotic disease progression through the production of excessive extracellular matrix (ECM) in response to signals from damaged epithelial and inflammatory cells. Nevertheless, epithelial cells are capable of expressing components of the ECM, cro...

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Bibliographic Details
Main Authors: Omar S. Qureshi, Hélène Bon, Breda Twomey, Gill Holdsworth, Kirsty Ford, Marianne Bergin, Linghong Huang, Mariusz Muzylak, Louise J. Healy, Vanessa Hurdowar, Timothy S. Johnson
Format: Article
Language:English
Published: The Company of Biologists 2017-10-01
Series:Biology Open
Subjects:
Collagen
Epithelial cell
Fibroblast
Extracellular matrix
Fibrosis
Fibronectin
Kidney
Transforming growth factor beta (TGF-β)
Transglutaminase
Online Access:http://bio.biologists.org/content/6/10/1423

Internet

http://bio.biologists.org/content/6/10/1423

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