Multitasking guardian of mitochondrial quality: Parkin function and Parkinson’s disease

Abstract The familial form of Parkinson’s disease (PD) is linked to mutations in specific genes. The mutations in parkin are one of the most common causes of early-onset PD. Mitochondrial dysfunction is an emerging active player in the pathology of neurodegenerative diseases, because mitochondria ar...

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Main Authors:	Iryna Kamienieva, Jerzy Duszyński, Joanna Szczepanowska
Format:	Article
Language:	English
Published:	BMC 2021-01-01
Series:	Translational Neurodegeneration
Subjects:	Mitochondria Parkinson’s disease Parkin PINK1 Mitophagy Parkin mutations
Online Access:	https://doi.org/10.1186/s40035-020-00229-8

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spelling	doaj-140c634219994be9ab73f2d3165ae3bc2021-01-24T12:45:52ZengBMCTranslational Neurodegeneration2047-91582021-01-0110111810.1186/s40035-020-00229-8Multitasking guardian of mitochondrial quality: Parkin function and Parkinson’s diseaseIryna Kamienieva0Jerzy Duszyński1Joanna Szczepanowska2Nencki Institute of Experimental Biology, Polish Academy of ScienceNencki Institute of Experimental Biology, Polish Academy of ScienceNencki Institute of Experimental Biology, Polish Academy of ScienceAbstract The familial form of Parkinson’s disease (PD) is linked to mutations in specific genes. The mutations in parkin are one of the most common causes of early-onset PD. Mitochondrial dysfunction is an emerging active player in the pathology of neurodegenerative diseases, because mitochondria are highly dynamic structures integrated with many cellular functions. Herein, we overview and discuss the role of the parkin protein product, Parkin E3 ubiquitin ligase, in the cellular processes related to mitochondrial function, and how parkin mutations can result in pathology in vitro and in vivo.https://doi.org/10.1186/s40035-020-00229-8MitochondriaParkinson’s diseaseParkinPINK1MitophagyParkin mutations
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Iryna Kamienieva Jerzy Duszyński Joanna Szczepanowska
spellingShingle	Iryna Kamienieva Jerzy Duszyński Joanna Szczepanowska Multitasking guardian of mitochondrial quality: Parkin function and Parkinson’s disease Translational Neurodegeneration Mitochondria Parkinson’s disease Parkin PINK1 Mitophagy Parkin mutations
author_facet	Iryna Kamienieva Jerzy Duszyński Joanna Szczepanowska
author_sort	Iryna Kamienieva
title	Multitasking guardian of mitochondrial quality: Parkin function and Parkinson’s disease
title_short	Multitasking guardian of mitochondrial quality: Parkin function and Parkinson’s disease
title_full	Multitasking guardian of mitochondrial quality: Parkin function and Parkinson’s disease
title_fullStr	Multitasking guardian of mitochondrial quality: Parkin function and Parkinson’s disease
title_full_unstemmed	Multitasking guardian of mitochondrial quality: Parkin function and Parkinson’s disease
title_sort	multitasking guardian of mitochondrial quality: parkin function and parkinson’s disease
publisher	BMC
series	Translational Neurodegeneration
issn	2047-9158
publishDate	2021-01-01
description	Abstract The familial form of Parkinson’s disease (PD) is linked to mutations in specific genes. The mutations in parkin are one of the most common causes of early-onset PD. Mitochondrial dysfunction is an emerging active player in the pathology of neurodegenerative diseases, because mitochondria are highly dynamic structures integrated with many cellular functions. Herein, we overview and discuss the role of the parkin protein product, Parkin E3 ubiquitin ligase, in the cellular processes related to mitochondrial function, and how parkin mutations can result in pathology in vitro and in vivo.
topic	Mitochondria Parkinson’s disease Parkin PINK1 Mitophagy Parkin mutations
url	https://doi.org/10.1186/s40035-020-00229-8
work_keys_str_mv	AT irynakamienieva multitaskingguardianofmitochondrialqualityparkinfunctionandparkinsonsdisease AT jerzyduszynski multitaskingguardianofmitochondrialqualityparkinfunctionandparkinsonsdisease AT joannaszczepanowska multitaskingguardianofmitochondrialqualityparkinfunctionandparkinsonsdisease
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Multitasking guardian of mitochondrial quality: Parkin function and Parkinson’s disease

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