Coping with brain amyloid: genetic heterogeneity and cognitive resilience to Alzheimer’s pathophysiology

Coping with brain amyloid: genetic heterogeneity and cognitive resilience to Alzheimer’s pathophysiology

Abstract Although abnormal accumulation of amyloid in the brain is an early biomarker of Alzheimer’s disease (AD), wide variation in cognitive trajectories during life can be seen in the setting of brain amyloidosis, ranging from maintenance of normal function to progression to dementia. It is widel...

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Bibliographic Details
Main Authors: Vijay K. Ramanan, Timothy G. Lesnick, Scott A. Przybelski, Michael G. Heckman, David S. Knopman, Jonathan Graff-Radford, Val J. Lowe, Mary M. Machulda, Michelle M. Mielke, Clifford R. Jack, Ronald C. Petersen, Owen A. Ross, Prashanthi Vemuri, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s
Amyloid
Cognitive decline
Genome-Wide Association Study
Resilience
Online Access:https://doi.org/10.1186/s40478-021-01154-1

Internet

https://doi.org/10.1186/s40478-021-01154-1

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