Neuropeptide Y1 Receptor Regulates Glucocorticoid-Induced Inhibition of Osteoblast Differentiation in Murine MC3T3-E1 Cells via ERK Signaling

Neuropeptide Y1 Receptor Regulates Glucocorticoid-Induced Inhibition of Osteoblast Differentiation in Murine MC3T3-E1 Cells via ERK Signaling

High dose glucocorticoid (GC) administration impairs the viability and function of osteoblasts, thus causing osteoporosis and osteonecrosis. Neuropeptide Y1 receptor (Y1 receptor) is expressed in bone tissues and cells, and regulates bone remodeling. However, the role of Y1 receptor in glucocorticoi...

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Bibliographic Details
Main Authors: Wei Yu, Chao Zhu, Wenning Xu, Leisheng Jiang, Shengdan Jiang
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:International Journal of Molecular Sciences
Subjects:
glucocorticoid
NPY (neuropeptide Y)
neuropeptide Y1 receptor
osteoblast
Online Access:http://www.mdpi.com/1422-0067/17/12/2150

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http://www.mdpi.com/1422-0067/17/12/2150

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