Oxidase Reactivity of Cu<sup>II</sup> Bound to <i>N</i>-Truncated Aβ Peptides Promoted by Dopamine

Oxidase Reactivity of Cu<sup>II</sup> Bound to <i>N</i>-Truncated Aβ Peptides Promoted by Dopamine

The redox chemistry of copper(II) is strongly modulated by the coordination to amyloid-β peptides and by the stability of the resulting complexes. Amino-terminal copper and nickel binding motifs (ATCUN) identified in truncated Aβ sequences starting with Phe4 show very high affinity for copper(II) io...

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Bibliographic Details
Main Authors: Chiara Bacchella, Simone Dell’Acqua, Stefania Nicolis, Enrico Monzani, Luigi Casella
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
copper
amyloid-β peptides
Alzheimer’s disease
oxidative stress
dopamine
neurodegeneration
Online Access:https://www.mdpi.com/1422-0067/22/10/5190

Internet

https://www.mdpi.com/1422-0067/22/10/5190

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