Impaired Autophagy and Defective T Cell Homeostasis in Mice with T Cell-Specific Deletion of Receptor for Activated C Kinase 1

Impaired Autophagy and Defective T Cell Homeostasis in Mice with T Cell-Specific Deletion of Receptor for Activated C Kinase 1

Autophagy plays a central role in maintaining T cell homeostasis. Our previous study has shown that hepatocyte-specific deficiency of receptor for activated C kinase 1 (RACK1) leads to lipid accumulation in the liver, accompanied by impaired autophagy, but its in vivo role in T cells remains unclear...

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Bibliographic Details
Main Authors: Guihua Qiu, Jian Liu, Qianqian Cheng, Qingyang Wang, Zhaofei Jing, Yujun Pei, Min Zhao, Jing Wang, Jessie Yanxiang Guo, Jiyan Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Immunology
Subjects:
receptor for activated C kinase 1
T cells
autophagy
apoptosis
acute liver injury
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00575/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00575/full

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