Boosting NAD+ with a small molecule that activates NAMPT

Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate determining step for NAD+ synthesis and is of interest as a drug target. Here the authors identify and characterize a small molecule NAMPT activator SBI-797812, elucidate its mode of action and show that it increases intracellular NMN...

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Main Authors:	Stephen J. Gardell, Meghan Hopf, Asima Khan, Mauro Dispagna, E. Hampton Sessions, Rebecca Falter, Nidhi Kapoor, Jeanne Brooks, Jeffrey Culver, Chris Petucci, Chen-Ting Ma, Steven E. Cohen, Jun Tanaka, Emmanuel S. Burgos, Jennifer S. Hirschi, Steven R. Smith, Eduard Sergienko, Anthony B. Pinkerton
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-11078-z

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spelling	doaj-1414d8924adf4074afe7c8dc6bbcf1cf2021-05-11T11:36:12ZengNature Publishing GroupNature Communications2041-17232019-07-0110111210.1038/s41467-019-11078-zBoosting NAD+ with a small molecule that activates NAMPTStephen J. Gardell0Meghan Hopf1Asima Khan2Mauro Dispagna3E. Hampton Sessions4Rebecca Falter5Nidhi Kapoor6Jeanne Brooks7Jeffrey Culver8Chris Petucci9Chen-Ting Ma10Steven E. Cohen11Jun Tanaka12Emmanuel S. Burgos13Jennifer S. Hirschi14Steven R. Smith15Eduard Sergienko16Anthony B. Pinkerton17Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute at Lake NonaCenter for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute at Lake NonaCenter for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute at Lake NonaCenter for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute at Lake NonaConrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute at Lake NonaConrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute at Lake NonaTranslational Research Institute for Metabolism and Diabetes, AdventHealth-OrlandoMetabolomics Core Facility, Sanford Burnham Prebys Medical Discovery Institute at Lake NonaMetabolomics Core Facility, Sanford Burnham Prebys Medical Discovery Institute at Lake NonaMetabolomics Core Facility, Sanford Burnham Prebys Medical Discovery Institute at Lake NonaConrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery InstituteDaiichi Sankyo, Inc., Global Business DevelopmentDaiichi Sankyo Co., Ltd, Shinagawa Research & Development CenterDepartment of Biochemistry, Albert Einstein College of MedicineDepartment of Chemistry, Binghamton UniversityCenter for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute at Lake NonaConrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery InstituteConrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery InstituteNicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate determining step for NAD+ synthesis and is of interest as a drug target. Here the authors identify and characterize a small molecule NAMPT activator SBI-797812, elucidate its mode of action and show that it increases intracellular NMN and NAD+ levels in cultured cells and elevates liver NAD+ in mice.https://doi.org/10.1038/s41467-019-11078-z
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Stephen J. Gardell Meghan Hopf Asima Khan Mauro Dispagna E. Hampton Sessions Rebecca Falter Nidhi Kapoor Jeanne Brooks Jeffrey Culver Chris Petucci Chen-Ting Ma Steven E. Cohen Jun Tanaka Emmanuel S. Burgos Jennifer S. Hirschi Steven R. Smith Eduard Sergienko Anthony B. Pinkerton
spellingShingle	Stephen J. Gardell Meghan Hopf Asima Khan Mauro Dispagna E. Hampton Sessions Rebecca Falter Nidhi Kapoor Jeanne Brooks Jeffrey Culver Chris Petucci Chen-Ting Ma Steven E. Cohen Jun Tanaka Emmanuel S. Burgos Jennifer S. Hirschi Steven R. Smith Eduard Sergienko Anthony B. Pinkerton Boosting NAD+ with a small molecule that activates NAMPT Nature Communications
author_facet	Stephen J. Gardell Meghan Hopf Asima Khan Mauro Dispagna E. Hampton Sessions Rebecca Falter Nidhi Kapoor Jeanne Brooks Jeffrey Culver Chris Petucci Chen-Ting Ma Steven E. Cohen Jun Tanaka Emmanuel S. Burgos Jennifer S. Hirschi Steven R. Smith Eduard Sergienko Anthony B. Pinkerton
author_sort	Stephen J. Gardell
title	Boosting NAD+ with a small molecule that activates NAMPT
title_short	Boosting NAD+ with a small molecule that activates NAMPT
title_full	Boosting NAD+ with a small molecule that activates NAMPT
title_fullStr	Boosting NAD+ with a small molecule that activates NAMPT
title_full_unstemmed	Boosting NAD+ with a small molecule that activates NAMPT
title_sort	boosting nad+ with a small molecule that activates nampt
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-07-01
description	Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate determining step for NAD+ synthesis and is of interest as a drug target. Here the authors identify and characterize a small molecule NAMPT activator SBI-797812, elucidate its mode of action and show that it increases intracellular NMN and NAD+ levels in cultured cells and elevates liver NAD+ in mice.
url	https://doi.org/10.1038/s41467-019-11078-z
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Boosting NAD+ with a small molecule that activates NAMPT

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