Bromodomain protein BRD4 is an epigenetic activator of B7-H6 expression in acute myeloid leukemia

Bromodomain protein BRD4 is an epigenetic activator of B7-H6 expression in acute myeloid leukemia

B7-H6, a ligand for the NK activating receptor NKp30, has been identified as a biomarker of poor prognosis in several solid cancers. However, little is known about the role of B7-H6 and the mechanisms that control its expression in acute myeloid leukemia (AML). Epigenome modulation, including epigen...

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Bibliographic Details
Main Authors: Aroa Baragaño Raneros, Ramon M Rodriguez, Aida Bernardo Flórez, Pilar Palomo, Enrique Colado, Alfredo Minguela, Beatriz Suárez Álvarez, Carlos López-Larrea
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:OncoImmunology
Subjects:
b7-h6
nkp30 ligand
bet proteins
brd4
aml
Online Access:http://dx.doi.org/10.1080/2162402X.2021.1897294

Internet

http://dx.doi.org/10.1080/2162402X.2021.1897294

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