Rare variants of the 3’-5’ DNA exonuclease TREX1 in early onset small vessel stroke [version 1; referees: 2 approved]

Rare variants of the 3’-5’ DNA exonuclease TREX1 in early onset small vessel stroke [version 1; referees: 2 approved]

Background: Monoallelic and biallelic mutations in the exonuclease TREX1 cause monogenic small vessel diseases (SVD). Given recent evidence for genetic and pathophysiological overlap between monogenic and polygenic forms of SVD, evaluation of TREX1 in small vessel stroke is warranted. Methods: We se...

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Bibliographic Details
Main Authors: Sarah McGlasson, Kristiina Rannikmäe, Steven Bevan, Clare Logan, Louise S. Bicknell, Alexa Jury, UK Young Lacunar Stroke Study, Andrew P. Jackson, Hugh S. Markus, Cathie Sudlow, David P.J. Hunt
Format: Article
Language:English
Published: Wellcome 2017-11-01
Series:Wellcome Open Research
Subjects:
Cerebrovascular Disease
Genomics
Online Access:https://wellcomeopenresearch.org/articles/2-106/v1

Internet

https://wellcomeopenresearch.org/articles/2-106/v1

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