Assessing the Pre-Analytical Stability of Small-Molecule Metabolites in Cerebrospinal Fluid Using Direct-Infusion Metabolomics

Assessing the Pre-Analytical Stability of Small-Molecule Metabolites in Cerebrospinal Fluid Using Direct-Infusion Metabolomics

Metabolomics studies aiming to find biomarkers frequently make use of historical or multicenter cohorts. These samples often have different pre-analytical conditions that potentially affect metabolite concentrations. We studied the effect of different storage conditions on the stability of small-mol...

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Bibliographic Details
Main Authors: Hanneke A. Haijes, Eline A.J. Willemse, Johan Gerrits, Wiesje M. van der Flier, Charlotte E. Teunissen, Nanda M. Verhoeven-Duif, Judith J.M. Jans
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Metabolites
Subjects:
biomarker stability
pre-analytical storage conditions
small-molecule metabolites
cerebrospinal fluid
metabolomics
direct-infusion mass spectrometry
dims
neurometabolic diagnostics
Online Access:https://www.mdpi.com/2218-1989/9/10/236

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https://www.mdpi.com/2218-1989/9/10/236

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