An Autism-Associated Neuroligin-3 Mutation Affects Developmental Synapse Elimination in the Cerebellum

An Autism-Associated Neuroligin-3 Mutation Affects Developmental Synapse Elimination in the Cerebellum

Neuroligin is a postsynaptic cell-adhesion molecule that is involved in synapse formation and maturation by interacting with presynaptic neurexin. Mutations in neuroligin genes, including the arginine to cystein substitution at the 451st amino acid residue (R451C) of neuroligin-3 (NLGN3), have been...

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Bibliographic Details
Main Authors: Esther Suk King Lai, Hisako Nakayama, Taisuke Miyazaki, Takanobu Nakazawa, Katsuhiko Tabuchi, Kouichi Hashimoto, Masahiko Watanabe, Masanobu Kano
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Neural Circuits
Subjects:
synapse elimination
neuroligin-3 mutation
autism
developing cerebellum
climbing fibers
Purkinje cell
Online Access:https://www.frontiersin.org/articles/10.3389/fncir.2021.676891/full

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https://www.frontiersin.org/articles/10.3389/fncir.2021.676891/full

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