A Structure-Function Diversity Survey of the RNA-Dependent RNA Polymerases From the Positive-Strand RNA Viruses

A Structure-Function Diversity Survey of the RNA-Dependent RNA Polymerases From the Positive-Strand RNA Viruses

The RNA-dependent RNA polymerases (RdRPs) encoded by the RNA viruses are a unique class of nucleic acid polymerases. Each viral RdRP contains a 500–600 residue catalytic module with palm, fingers, and thumb domains forming an encircled human right hand architecture. Seven polymerase catalytic motifs...

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Bibliographic Details
Main Authors: Hengxia Jia, Peng Gong
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Microbiology
Subjects:
positive-strand RNA virus
RNA-dependent RNA polymerase
genome replication
structure
catalytic motif
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.01945/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.01945/full

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