Alpha-synuclein overexpression in the olfactory bulb initiates prodromal symptoms and pathology of Parkinson’s disease

Alpha-synuclein overexpression in the olfactory bulb initiates prodromal symptoms and pathology of Parkinson’s disease

Abstract Background Parkinson’s disease (PD) is a neurodegenerative disease characterized by intraneuronal Lewy Body (LB) aggregates composed of misfolded alpha-synuclein (α-syn). The spread of misfolded α-syn follows a typical pattern: starting in the olfactory bulb (OB) and the gut, this pathology...

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Bibliographic Details
Main Authors: Haichen Niu, Lingyu Shen, Tongzhou Li, Chao Ren, Sheng Ding, Lei Wang, Zhonghai Zhang, Xiaoyu Liu, Qiang Zhang, Deqin Geng, Xiujuan Wu, Haiying Li
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Translational Neurodegeneration
Subjects:
Alpha-synuclein
Prodromal animal model
Parkinson’s disease
Olfactory bulb
Autophagy
Online Access:http://link.springer.com/article/10.1186/s40035-018-0128-6

Internet

http://link.springer.com/article/10.1186/s40035-018-0128-6

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