Alpha-synuclein overexpression in the olfactory bulb initiates prodromal symptoms and pathology of Parkinson’s disease
Abstract Background Parkinson’s disease (PD) is a neurodegenerative disease characterized by intraneuronal Lewy Body (LB) aggregates composed of misfolded alpha-synuclein (α-syn). The spread of misfolded α-syn follows a typical pattern: starting in the olfactory bulb (OB) and the gut, this pathology...
Main Authors: | Haichen Niu, Lingyu Shen, Tongzhou Li, Chao Ren, Sheng Ding, Lei Wang, Zhonghai Zhang, Xiaoyu Liu, Qiang Zhang, Deqin Geng, Xiujuan Wu, Haiying Li |
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Format: | Article |
Language: | English |
Published: |
BMC
2018-09-01
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Series: | Translational Neurodegeneration |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s40035-018-0128-6 |
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