Identification of Potential Binders of Mtb Universal Stress Protein (Rv1636) Through an in silico Approach and Insights Into Compound Selection for Experimental Validation

Identification of Potential Binders of Mtb Universal Stress Protein (Rv1636) Through an in silico Approach and Insights Into Compound Selection for Experimental Validation

Millions of deaths caused by Mycobacterium tuberculosis (Mtb) are reported worldwide every year. Treatment of tuberculosis (TB) involves the use of multiple antibiotics over a prolonged period. However, the emergence of resistance leading to multidrug-resistant TB (MDR-TB) and extensively drug-resis...

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Bibliographic Details
Main Authors: Sohini Chakraborti, Moubani Chakraborty, Avipsa Bose, Narayanaswamy Srinivasan, Sandhya S. Visweswariah
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Molecular Biosciences
Subjects:
virtual screening
molecular docking
universal stress protein
Rv1636
anti-tubercular compounds
computational drug discovery
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.599221/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2021.599221/full

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