De Novo Development of mtDNA Deletion Due to Decreased POLG and SSBP1 Expression in Humans

De Novo Development of mtDNA Deletion Due to Decreased POLG and SSBP1 Expression in Humans

Defects in the mitochondrial genome (mitochondrial DNA (mtDNA)) are associated with both congenital and acquired disorders in humans. Nuclear-encoded DNA polymerase subunit gamma (<i>POLG</i>) plays an important role in mtDNA replication, and proofreading and mutations in <i>POLG&l...

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Bibliographic Details
Main Authors: Yeonmi Lee, Taeho Kim, Miju Lee, Seongjun So, Mustafa Zafer Karagozlu, Go Hun Seo, In Hee Choi, Peter C. W. Lee, Chong-Jai Kim, Eunju Kang, Beom Hee Lee
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Genes
Subjects:
mtDNA deletion
POLG
SSBP1
Pearson syndrome
human
Online Access:https://www.mdpi.com/2073-4425/12/2/284

Internet

https://www.mdpi.com/2073-4425/12/2/284

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