Time-Dependent Nerve Growth Factor Signaling Changes in the Rat Retina During Optic Nerve Crush-Induced Degeneration of Retinal Ganglion Cells

Time-Dependent Nerve Growth Factor Signaling Changes in the Rat Retina During Optic Nerve Crush-Induced Degeneration of Retinal Ganglion Cells

Nerve growth factor (NGF) is suggested to be neuroprotective after nerve injury; however, retinal ganglion cells (RGC) degenerate following optic-nerve crush (ONC), even in the presence of increased levels of endogenous NGF. To further investigate this apparently paradoxical condition, a time-course...

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Bibliographic Details
Main Authors: Louise A. Mesentier-Louro, Sara De Nicolò, Pamela Rosso, Luigi A. De Vitis, Valerio Castoldi, Letizia Leocani, Rosalia Mendez-Otero, Marcelo F. Santiago, Paola Tirassa, Paolo Rama, Alessandro Lambiase
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:International Journal of Molecular Sciences
Subjects:
optic-nerve crush
retinal ganglion cells
nerve growth factor
glaucoma
Online Access:http://www.mdpi.com/1422-0067/18/1/98

Internet

http://www.mdpi.com/1422-0067/18/1/98

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