Tartrate-resistant acid phosphatase (TRAP/ACP5) promotes metastasis-related properties via TGFβ2/TβR and CD44 in MDA-MB-231 breast cancer cells

Tartrate-resistant acid phosphatase (TRAP/ACP5) promotes metastasis-related properties via TGFβ2/TβR and CD44 in MDA-MB-231 breast cancer cells

Abstract Background Tartrate-resistant acid phosphatase (TRAP/ACP5), a metalloenzyme that is characteristic for its expression in activated osteoclasts and in macrophages, has recently gained considerable focus as a driver of metastasis and was associated with clinically relevant parameters of cance...

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Bibliographic Details
Main Authors: Anja Reithmeier, Elena Panizza, Michael Krumpel, Lukas M. Orre, Rui M. M. Branca, Janne Lehtiö, Barbro Ek-Rylander, Göran Andersson
Format: Article
Language:English
Published: BMC 2017-09-01
Series:BMC Cancer
Subjects:
ACP5
TRAP
5-PNA
TGFβ2
CD44
MDA-MB-231
Online Access:http://link.springer.com/article/10.1186/s12885-017-3616-7

Internet

http://link.springer.com/article/10.1186/s12885-017-3616-7

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