Tetrahydrouridine inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels.

Tetrahydrouridine inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels.

Tetrahydrouridine (THU) is a well characterized and potent inhibitor of cytidine deaminase (CDA). Highly expressed CDA catalyzes and inactivates cytidine analogues, ultimately contributing to increased gemcitabine resistance. Therefore, a combination therapy of THU and gemcitabine is considered to b...

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Bibliographic Details
Main Authors: Naotake Funamizu, Curtis Ray Lacy, Kaori Fujita, Kenei Furukawa, Takeyuki Misawa, Katsuhiko Yanaga, Yoshinobu Manome
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3353937?pdf=render

Internet

http://europepmc.org/articles/PMC3353937?pdf=render

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