Many Different LINE-1 Retroelements Are Activated in Bladder Cancer

Many Different LINE-1 Retroelements Are Activated in Bladder Cancer

Human genomes contain about 100,000 LINE-1 (L1) retroelements, of which more than 100 are intact. L1s are normally tightly controlled by epigenetic mechanisms, which often fail in cancer. In bladder urothelial carcinoma (UC), particularly, L1s become DNA-hypomethylated, expressed and contribute to g...

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Bibliographic Details
Main Authors: Patcharawalai Whongsiri, Wolfgang Goering, Tobias Lautwein, Christiane Hader, Günter Niegisch, Karl Köhrer, Michèle J. Hoffmann, Wolfgang A. Schulz
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
LINE-1 retroelements
urothelial carcinoma
histone modifications
RNA immunoprecipitation
nanopore sequencing
chromatin immunoprecipitation
Online Access:https://www.mdpi.com/1422-0067/21/24/9433

Internet

https://www.mdpi.com/1422-0067/21/24/9433

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