Phosphorylation of the amino-terminus of the AGC kinase Gad8 prevents its interaction with TORC2

Cell proliferation, metabolism, migration and survival are coordinated through the tight control of two target of rapamycin (TOR) kinase complexes: TORC1 and TORC2. Here, we show that a novel phosphorylation of fission yeast Gad8 (AGC kinase) on the evolutionarily conserved threonine 6 (Thr6) preven...

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Bibliographic Details
Main Authors: Wei Du, Gabriella M. Forte, Duncan Smith, Janni Petersen
Format: Article
Language:English
Published: The Royal Society 2016-01-01
Series:Open Biology
Subjects:
pkc
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.150189