Gallbladder wall abnormality in biliary atresia of mouse Sox17+/− neonates and human infants

Gallbladder wall abnormality in biliary atresia of mouse Sox17+/− neonates and human infants

Biliary atresia (BA) is characterized by the inflammation and obstruction of the extrahepatic bile ducts (EHBDs) in newborn infants. SOX17 is a master regulator of fetal EHBD formation. In mouse Sox17+/− BA models, SOX17 reduction causes cell-autonomous epithelial shedding together with the ectopic...

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Bibliographic Details
Main Authors: Mami Uemura, Mayumi Higashi, Montri Pattarapanawan, Shohei Takami, Naoki Ichikawa, Hiroki Higashiyama, Taizo Furukawa, Jun Fujishiro, Yuki Fukumura, Takashi Yao, Tatsuro Tajiri, Masami Kanai-Azuma, Yoshiakira Kanai
Format: Article
Language:English
Published: The Company of Biologists 2020-04-01
Series:Disease Models & Mechanisms
Subjects:
sox17
cholecystitis
peribiliary gland
pbg
pseudopyloric gland
ppg
human
mouse
biliary atresia
Online Access:http://dmm.biologists.org/content/13/4/dmm042119

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http://dmm.biologists.org/content/13/4/dmm042119

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