FGF21 Protects against Aggravated Blood-Brain Barrier Disruption after Ischemic Focal Stroke in Diabetic db/db Male Mice via Cerebrovascular PPARγ Activation

FGF21 Protects against Aggravated Blood-Brain Barrier Disruption after Ischemic Focal Stroke in Diabetic db/db Male Mice via Cerebrovascular PPARγ Activation

Recombinant fibroblast growth factor 21 (rFGF21) has been shown to be potently beneficial for improving long-term neurological outcomes in type 2 diabetes mellitus (T2DM) stroke mice. Here, we tested the hypothesis that rFGF21 protects against poststroke blood−brain barrier (BBB) damage in...

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Bibliographic Details
Main Authors: Yinghua Jiang, Li Lin, Ning Liu, Qingzhi Wang, Jing Yuan, Yadan Li, Kelly K. Chung, Shuzhen Guo, Zhanyang Yu, Xiaoying Wang
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
focal ischemic stroke
type 2 diabetes
db/db mouse
fibroblast growth factor 21
blood—brain barrier
human brain microvascular endothelial cell
Online Access:https://www.mdpi.com/1422-0067/21/3/824

Internet

https://www.mdpi.com/1422-0067/21/3/824

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