IL-1α mediated chorioamnionitis induces depletion of FoxP3+ cells and ileal inflammation in the ovine fetal gut.

IL-1α mediated chorioamnionitis induces depletion of FoxP3+ cells and ileal inflammation in the ovine fetal gut.

Endotoxin induced chorioamnionitis increases IL-1 and provokes an inflammatory response in the fetal ileum that interferes with intestinal maturation. In the present study, we tested in an ovine chorioamnionitis model whether IL-1 is a major cytokine driving the inflammatory response in the fetal il...

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Bibliographic Details
Main Authors: Tim G A M Wolfs, Suhas G Kallapur, Graeme R Polglase, J Jane Pillow, Ilias Nitsos, John P Newnham, Claire A Chougnet, Elke Kroon, Julia Spierings, Coen H M P Willems, Alan H Jobe, Boris W Kramer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3066237?pdf=render

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http://europepmc.org/articles/PMC3066237?pdf=render

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