Gliclazide Prevents 5-FU-Induced Oral Mucositis by Reducing Oxidative Stress, Inflammation, and P-Selectin Adhesion Molecules

Gliclazide Prevents 5-FU-Induced Oral Mucositis by Reducing Oxidative Stress, Inflammation, and P-Selectin Adhesion Molecules

Oral mucositis (OM) is one of the main side effects of the head and neck cancer treatment, particularly radiotherapy and/or chemotherapy. OM is characterized by ulcers, erythema, dysphagia, xerostomia, and increased susceptibility to opportunistic infections. In the perspective of finding pharmacolo...

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Bibliographic Details
Main Authors: Cristiane Assunção da Costa Cunha Mafra, Roseane Carvalho Vasconcelos, Caroline Addison Carvalho Xavier de Medeiros, Renata Ferreira de Carvalho Leitão, Gerly Anne de Castro Brito, Deiziane Viana da Silva Costa, Gerlane Coelho Bernardo Guerra, Raimundo Fernandes de Araújo, Aldo Cunha Medeiros, Aurigena Antunes de Araújo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Physiology
Subjects:
5-fluorouracil
oral mucositis
gliclazide
oxidative stress
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00327/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.00327/full

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