Evolution of the p53-MDM2 pathway

Abstract Background The p53 signalling pathway, which controls cell fate, has been extensively studied due to its prominent role in tumor development. The pathway includes the tumor supressor protein p53, its vertebrate paralogs p63 and p73, and their negative regulators MDM2 and MDM4. The p53/p63/p...

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Bibliographic Details
Main Authors: Emma Åberg, Fulvio Saccoccia, Manfred Grabherr, Wai Ying Josefin Ore, Per Jemth, Greta Hultqvist
Format: Article
Language:English
Published: BMC 2017-08-01
Series:BMC Evolutionary Biology
Subjects:
p53
MDM
Online Access:http://link.springer.com/article/10.1186/s12862-017-1023-y