The ARFRP1-dependent Golgi scaffolding protein GOPC is required for insulin secretion from pancreatic β-cells

The ARFRP1-dependent Golgi scaffolding protein GOPC is required for insulin secretion from pancreatic β-cells

Objective: Hormone secretion from metabolically active tissues, such as pancreatic islets, is governed by specific and highly regulated signaling pathways. Defects in insulin secretion are among the major causes of diabetes. The molecular mechanisms underlying regulated insulin secretion are, howeve...

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Bibliographic Details
Main Authors: Ilka Wilhelmi, Stephan Grunwald, Niclas Gimber, Oliver Popp, Gunnar Dittmar, Anup Arumughan, Erich E. Wanker, Thomas Laeger, Jan Schmoranzer, Oliver Daumke, Annette Schürmann
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Metabolism
Subjects:
Insulin secretion
Endosomal sorting
SNARE proteins
trans-Golgi network
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820302258

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http://www.sciencedirect.com/science/article/pii/S2212877820302258

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