Exploring the binding nature of pyrrolidine pocket-dependent interactions in the polo-box domain of polo-like kinase 1.

Exploring the binding nature of pyrrolidine pocket-dependent interactions in the polo-box domain of polo-like kinase 1.

BACKGROUND: Over the years, a great deal of effort has been focused on the design and synthesis of potent, linear peptide inhibitors targeting the polo-like kinase 1 (Plk1), which is critically involved in multiple mitotic processes and has been established as an adverse prognostic marker for tumor...

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Main Authors: Ravichandran N Murugan, Mija Ahn, Woo Cheol Lee, Hye-Yeon Kim, Jung Hyun Song, Chaejoon Cheong, Eunha Hwang, Ji-Hyung Seo, Song Yub Shin, Sun Ho Choi, Jung-Eun Park, Jeong Kyu Bang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3819306?pdf=render

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http://europepmc.org/articles/PMC3819306?pdf=render

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