Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains.
In embryonic stem (ES) cells, bivalent chromatin domains with overlapping repressive (H3 lysine 27 tri-methylation) and activating (H3 lysine 4 tri-methylation) histone modifications mark the promoters of more than 2,000 genes. To gain insight into the structure and function of bivalent domains, we...
Main Authors: | , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2008-10-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC2567431?pdf=render |